8/22/2023 0 Comments Define redacted medically![]() ![]() These unmonitored records may have important data which do not find its way to the CRF. Such as: Diaries of coordinator, inpatient records of the hospital, electronic records, etc., for the simple reason that the staff does not realize that these form a part of source record. In India, the documentation in routine medical practice may not be as extensive as what would be expected for clinical research.Īdditional unmonitored medical records are discovered at the time of audits/inspections. As a result the principal investigator (PI) and staff may continue documentation per the routine medical practice. Inadequacies in documentation could be the result of lack of training and experience in good understanding of clinical research and documentation requirements. Moreover clinical research happens over a long period of time which adds to the challenge of maintaining continuity in the documentation practice. Thus rendering this process to be complicated and posing challenges to meet requirements. WHAT ARE THE POSSIBLE ROOT CAUSES FOR REPEATED DEFICIENCIES IN SOURCE DOCUMENTATION?Ĭlinical research documentation involves a variety of documents from various sources and is often completed by several people. Let‘s look at these attributes described by different authorities collectively. EMA has added some more ‘letters’ to describe qualities of good source documentation particularly for electronic documentation. These are also adapted by World Health Organization (WHO). Key attributes for good documentation were first described by US-FDA in the form of ALCOA -attributable, legible, contemporaneous, original and accurate. This definition describes the various types of documents which collectively form the source document. Original documents, data and records (e.g., hospital records, clinical and office charts, laboratory notes, memoranda, subjects’ diaries or evaluation checklists, pharmacy dispensing records, recorded data from automated instruments, copies or transcriptions certified after verification as being accurate copies, microfiches, photographic negatives, microfilm or magnetic media, X-rays, subject files, and records kept at the pharmacy, at the laboratories and at medico-technical departments involved in the clinical trial). There can not be two thoughts to emphasize the need for reliable and quality documentation. Irrespective of clinical trial, accurate documentation supports the fundamental principle of protecting subject’s rights, safety and well-being. It serves as the complete medical record of the subject as the reference to the treating physician at any point of time.įinally it forms a strong foundation for the data that gets transcribed into a CRF which ultimately gets translated into a clinical study report. It records the accountability of the investigational product dispensed, consumed and returned by the subject. It documents the progress of the subject from consenting till the subject completes the study. It is the tool which confirms the eligibility criteria of the subject in the given trial. Source documentation is the medical record of the subject before, during and after the trial. Documentation should be such that it is able to provide audit trail to permit investigation if and when required. It should enable an independent observer to reconfirm the data. The most important purpose of source documentation in a clinical trial is to reconstruct the trial as it happened. To understand the importance of good source documentation we should first review the purpose of source documentation. WHAT IS THE PURPOSE OF SOURCE DOCUMENTATION? There were two underlying potential issues here: For the trial subjects there were no other hand-written progress notes which the site would normally use for routine patients. ![]() This method was adopted only for clinical trial subjects. In normal practice the site did not use MS word to generate medical records. The site was actually using MS word to document the data collected during the study. I would like to share an experience at a recent investigator site audit.ĭuring the audit opening meeting we were informed that all the source data is on paper and no electronic documentation is used. Not surprisingly, clinical trial monitors and auditors also report documentation issues as a frequent area of GCP concern. Similarly, source documentation issues ranked 5th among the top 10 findings from European Medicines Agency (EMA) inspections of investigator sites in 2009 and in some instances the findings were classified ‘critical’. Inadequate/inaccurate case histories form the second most commonly cited deficiency in US-FDA inspections of clinical investigator sites. ![]()
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8/22/2023 0 Comments Sweet home 3d tutoriel![]() ![]() ![]() The paid version for Windows (available on Microsoft Store or on Amazon) and Mac users (available on the Mac App Store) is bundled with 1500 pieces of furniture and 418 textures.īut you can still download and use Sweet Home 3D free of charge, either for personal or commercial purposes. However, you might need knowledge of how to use home design software (especially if you’ve not used any before) to be able to explore all the features. The Sweet Home 3D application comes preinstalled with several easy-to-use features. The Uninstallation Wizard will run and completely delete the application from your computer.The Sweet Home 3D Uninstallation Wizard will open and ask you if you want to uninstall the application.Scroll down to locate the Sweet Home 3D application in the list of installed programs, then click the Uninstall button.Type “Add or Remove Programs” in the Windows search bar and press the Enter key.To delete the program completely from your PC, follow these simple steps: But if you’re still looking for architectural design software that offers more features, check out the free alternatives below. The interface below is what you`ll see.Īfter you’re finished with Sweet Home 3D, you can completely remove it from your computer in a few easy steps. Launch the application once the installation is complete.Once the download is finished, run the setup file to install the software on your computer.Once the download page opens, click “Download” to automatically download the setup file to your computer.Click on the Download button on the sidebar to open the Sweet Home 3D download page.How to Download and Install Sweet Home 3D for PC for Free Although there is a paid version of the software, I’ll show you how to download the fully-functional Sweet Home 3D software to your PC for free. Other features of the application include creating photorealistic images and videos with various light sources. You can update colors, texture, size, and orientation for furniture, walls, floors, and ceilings. The application helps users draw house plans and arrange furniture inside the house in 2D, and then view the results in 3D. Sweet Home 3D is a great interior design software available for free download for both Windows and Mac users. Best Parental Control for iPhone & iPad.IPVanish VPN vs Private Internet Access. ![]() 8/22/2023 0 Comments Whiskey wings shawnee ok![]() ![]() Episodes are shot in real-time for 5-day stretches, however, considerable planning happens ahead of time.Ģ47 episodes, including 1 removed episode ( unintentionally aired), have aired as of May 28, 2023. Throughout the show's history, multiple bars have restored their original name or motif after filming wraps. Additionally, the businesses featured on Bar Rescue are under no obligation to follow any of the rescue protocols or keep any of the changes. All renovations and improvements are paid for by sponsors, with no cost to the businesses. It is commonly believed that Taffer takes a percentage of the businesses he rescues however, this is totally untrue. ![]() It stars Jon Taffer (a long-time food and beverage industry consultant specializing in nightclubs and pubs), who offers his professional expertise, access to service industry experts, and renovations and equipment to desperately failing bars in order to save them from closing. Beef on weck is a rare roast beef sandwich on a kimmelweck roll (a hard German bun topped with caraway seeds and salt), dipped in jus and served with a smear of horseradish.įun fact: Some still call Buffalo Wild Wings "BW3s", and it's thought that the Western New York-based restaurant chain's elusive third W once stood for "weck".Bar Rescue is an American reality TV series that premiered on Paramount Network (formerly Spike) on July 17, 2011. Their current chef has traveled throughout Asia and is constantly mixing up new sauce flavors, like sweet chili gochujang (drool.) Visit Buffalo Niagara suggested the five wings plus beef on weck special, which pairs two classic Buffalo foods. Cole's has an impressive menu of craft beers on tap, and their menu meshes old-school classics with unexpected flavors (think, Buffalo chicken egg rolls), and, of course, their wings are solid. Take the time to admire the antiques all around (there's a rowboat from the 1960s Olympic, carousel horses, all kinds of gems like that) before you sit down. Here's our guide to the official Buffalo Wing Trail!Ĭole's Restaurant's can best be described as "quirky" or "eccentric" or even "totally freakin' awesome". Most of these joints are neighborhood bars, with their own distinctive vibes and their own unique twists on the classic Buffalo wing. In fact, there are so many awesome bars in Buffalo that serve outstanding Buffalo wings that Visit Buffalo Niagara has an entire Buffalo wing trail. They're just as much a staple in bars across Buffalo as they are in bars across the country. and while all of that is great (especially Buffalo chicken pizza), there's no substitute for the real thing. Or book now at one of our other 1834 great restaurants. You can get Buffalo chicken pizza, Buffalo chicken-flavored potato chips, Buffalo chicken wraps and sandwiches and dips and mac and cheese. Get menu, photos and location information for Grand Casino Resort - Grandstand Grill in Shawnee, OK. Since then, Buffalo wings have become a phenomenon. Either way, she served the fried wings with celery and blue cheese dressing, and the rest, as they say, is history. She threw a batch of chicken wings (at the time, wings were an undesirable cut of chicken, mostly just used for stock, soup, and broth) into the fryer and then tossed them in a hot sauce (allegedly made with Frank's Red Hot.) Some stories claim that Teressa wasn't even supposed to have chicken wings in their fridge that night they were accidentally delivered instead of the chicken necks and backs the Bellissimos needed for their spaghetti sauce. Her son Dominic rolled in late one Friday night in 1964, and she decided to make something special for him and the other bar patrons to nosh on. The story of how Buffalo wings came to be is a bit murky, but the official story holds that Teressa Bellissimo was working the kitchen at the Anchor Bar, which she and her husband owned. It's no surprise that from the moment they were invented, they were an instant hit. Most importantly, though, they are the perfect complement to a cold beer. 4.20 Golden Corral Buffet & Grill (4901 reviews). And wings are fun to eat what other food can say that? Sure, you might get a little messy, but that's life. 4.20 Toby Keiths I Love This Bar & Grill (5286 reviews) Down-home American fare & live music. Rodriguez National Mojito Day National Michelada Day National Scotch Day National Chicken Wing Day UFC. They're deliciously crispy and buttery and spicy. National Fried Chicken Day UFC 290: Volkanovski v. Is there any food more perfect than the Buffalo wing? I think not. ![]() 8/22/2023 0 Comments Hsa eligible items 2021![]() Or you switched jobs and they don’t offer an HSA-eligible health plan. Perhaps you changed health insurance plans and you’re no longer HSA-eligible. If You’re No Longer Eligible for Contributions in 2023 Consider how nice it’ll be to see that money grow by the time you’re ready to retire…or when you need it for an unforeseen medical expense.Īnd always remember: time is one of your best advantages to investing, so it’s smart to think of contributing to your HSA as part of your overall retirement strategy. But! If you do have some extra cash, say, from that side-hustle, or maybe your rich aunt gave you a nice chunk of change for your birthday, think about socking those dollars away instead of spending them on a weekend getaway, or that new TV you’ve been eyeing. Well, sometimes circumstances get in the way, and that cash needs to work for you in the immediate. So why not contribute as much as you can and max out your account out each year? The whole point of an HSA is to make your hard-earned dollars work for you, as well as to help you save on medical costs (duh). Well, since your HSA is tax-free and any contribution you make to it (except direct, pre-tax paycheck deductions) is tax-deductible, making a contribution before the tax deadline helps you maximize your tax benefits, which is to say: you’re paying less in overall taxes. Now… let’s say you added in a side hustle in 2022 and it did really well, which also means you’ll need to pay more in taxes. Always check with the IRS for the specific year’s date. Contributions are based on tax year so you usually have until April 18th to contribute towards 2022. The contribution limits for 2022 are $3,650 for individuals and $7,300 for a family. As in its epic triple-tax-advantage: withdrawals for qualified medical expenses are tax-free, contributions to your HSA lower your taxable income, and any interest you earn in your account grows tax-free. However, contributing to the previous year has some specific perks…Ī major reason to have an HSA is for its incredible tax benefits. No matter how you slice it, whether you’re contributing to your HSA for this year or last, you’re taking the right step with your finances. No lie! This hack is like how retirement accounts work in that you can contribute towards 2022 for tax purposes, e ven though we’re well into 2023. When it comes to health savings account (HSA) contributions… there’s quite a bit to talk about! Although it may sound strange, putting money from this year toward your HSA contribution limit from last year can seriously benefit your wallet. Dependent Care FSAs are not Health Care FSAs for your dependents.Have some extra money and thinking about putting it towards your health savings account (HSA) contributions in 2023? Not so fast! Here’s why.
8/22/2023 0 Comments Tomb raider next movie![]() ![]() There is hardly a stone surface anywhere in the film that will not grindingly reveal a trapdoor, a recessed panel, or a large metal spike – and all with a certain mysterious engineering that provides for a considerable amount of movement without a power source, in the much-loved and time-honoured manner.Īnd throughout Vikander maintains a kind of serene evenness of manner. In the course of all this, Lara will undergo all sort of Indiana Jones-esque challenges and ordeals, a borrowing so casual and widespread that it’s easy to forget that it is actually derivative. This remarkable document is to lead her on a journey to Hong Kong and then this Japanese island itself, where she will discover the terrifying truth about what happened to the man in her life. At one stage, she says, proudly: “I’m sorry, I’m not that sort of Croft.” The Croft she’s like is Annabel.Īn ancient Japanese puzzle box, the property of the late Lord Richard, is handed over to her – and in it she instantly finds a vital piece of paper, and then her dad’s notebook, which contains top-secret handwritten notes, maps and line drawings of that dangerous island, rather like Alfred Wainwright’s books about the Lake District. The family name is very important to her. Naturally, this grownup Lara Croft is still supposed to be a total badass, proficient in kick-boxing and mixed martial arts she has a job as a bike messenger in London, sexily toughing it out in that streetwise way of hers, until she is ready to accept that her wealthy aristocratic father did in fact die so she can inherit the title, effective control of his company and a colossal amount of money. But Lord Richard disappeared some time ago, on a mission to discover the tomb of the ancient Japanese queen Himiko, on a remote and dangerous island – and he is now presumed dead. ![]() ![]() In one flashback, he is wearing a hideous chocolate-brown double-breasted suit. It will tie in to the recently-announced TV show and the next video game as part of a connected franchise. This guy is always smiling wisely in soft-focus flashback in the grounds of Croft Manor, which has the same totemic importance as Wayne Manor, always kissing the demure infant Lara’s forehead or indeed brushing his fingers with his lips and touching her forehead (eeuuww) prior to going off on one of his dangerous ethnological adventures. Published A new Tomb Raider film is in the works. ![]() 8/22/2023 0 Comments Collapse and rewind free read![]() ![]() Toonily - Read Manhwa, Comics, Webtoon Online. You are reading Collapse & Rewind manga, one of the most popular manga covering in Drama, Romance, Smut genres, written by Lemoncandy Rodong at MangaMirror. You can read the next chapter of Collapse & Rewind Chapter 1 or previous chapter Collapse & Rewind Chapter 2. The first chapter has been rated 4.2 by users, and you can find the full list of chapters on Toonily. It is about how time passes and what happens to people who experience a time-lapse. You can use the Bookmark button to add Collapse & Rewind to your favorite list, so you can get the latest Collapse & Rewind manhwa updates. If you are looking for a free manga to read, then you should check out the story of Collapse and Rewind. IConnectFX is a free platform for video sharing, streaming, online conferencing. On a totally unrelated note: Thousands of you, at any given moment, are apparently watching the livestream of I-95 repair in Northeast Philadelphia, a process that will likely take weeks or months. It's great if you follow us daily and enjoy other stories here apart from Collapse & Rewind Chapter 1. Read Collapse & Rewind Online Free Chapters - Raw manhwa Sign in Sign up Home All Mangas Collapse & Rewind Collapse & Rewind 4.7 Rating Average 4.7 / 5 out of 33 Rank 86th, it has 158. rewind at least once to see that its pulled with a fishing line. Toonily is a great manga page, suitable for all devices, and of course you will be happy to come to us. Now let's read Collapse & Rewind Chapter 1. The story was written by Lemoncandy and illustrations by Rodong. This OnGoing manhwa was released on 2019. Some new manhwa are updated as Nano Machine, The Hypnosis App was Fake, A Tale of Tails, Meeting you again, My Younger Colleague Is Too Unfriendly…, Insertion Into a Lewd Spot…!, Subscribe and Like Raw, Depths of Malice, I Can’t Stand It, Ajumma, Please not at School! Raw, Girls’ University Club Sex Training, The Hole is Open, Secret Siblings Raw, My Illustrator Raw, The Law of Reincarnation Raw, Bunking Bed.Īt Toonily, we guarantee that will update the fastest, but the latest chapter of the hottest manga present. OnGoing Comments 415 Users bookmarked This Read First Read Last Summary Read Collapse & Rewind Manhwa Hentai also known as (AKA). You can find the manhwa, comics, webtoon updated latest ears Of course at Toonily you will be reading Collapse & Rewind Chapter 1 for free. In addition to Collapse & Rewind Chapter 1, you can find a full list of Collapse & Rewind chapters here. You are reading Chapter 1 of the manhwa Collapse & Rewind, one of the stories of genres, popular and many readers.Ĭollapse & Rewind Chapter 1 is about undefined readings, and is rated 4.2 from users ![]() 8/22/2023 0 Comments Lease chevy trax for sale![]() ![]() How to Set Up Your Test Drive in Montebello, CA Every truck model made by Chevy has the excellent capability and a high-strength frame to transport your equipment safely. If you're looking for a more durable option, especially for the job site, check out one of the medium or heavy-duty trucks in Montebello - a short drive from Buena Park. Why are you interested in a new Chevy truck? If you want to haul your camper or small boat, you can do well with a light-duty model. Pickup trucks can be used for recreation or work. ![]() You can compare all the latest Chevy SUVs before visiting Chevrolet of Montebello. If you want an SUV that seats five and can get more miles per gallon, go with a compact crossover SUV. These midsize and full-size SUVs can haul more. Do you need to seat more than five people? Check out one of the larger new Chevrolet SUVs for sale in Montebello. In the SUV segment of the new Chevrolet inventory, you'll find models have that two and three rows of seating. ![]() If you want to get better gas mileage for trips around LA, you'll do well by financing or leasing the: You'll also care about responsive handling and a smooth ride. Instead, car shoppers near Whittier look at city and highway fuel economy. Those looking for a new car don't need the cargo capacity of an SUV or the towing capacity of a truck. Under the car category of the new Chevrolet inventory, you'll find a mix of convertibles, coupes, sedans, and hatchbacks. Start the process by researching the latest models from wherever you live in California. A perfect Chevy model is waiting for you here in Montebello, CA, from a family-sized SUV to a heavy-duty truck. If you'd like to lease or buy American-made transportation near Buena Park, we'll find you a match in the Chevrolet showroom. Our state-of-the-art Montebello establishment is only 20 minutes from the bustling city of Los Angeles. Chevrolet of Montebello is one of many certified Chevy dealers on the west coast. Every Chevrolet model stands out because of its superior reliability, craftsmanship, and long-lasting value. It manufactures coupes, sedans, crossovers, SUVs, and trucks. In over a century, Chevy has become of the most sought-after automakers. Shop the Latest Chevy Cars, SUVs, and Trucks Near Los AngelesĬhevrolet is an American-made brand that's been going strong since 1911. ![]() 8/22/2023 0 Comments Green to red apple color test![]() ![]() Regardless of what your local supermarket has to offer, you can grow almost any kind of apple, as long as it suits your hardiness zone. And while some people have their favorite apple varieties, they're probably limited by Ruokauppa's options.īut there are no such limits for a gardener. Apples come in many colors, sizes, and flavors. Google the word "apple" and you'll find thousands of recipes that cover everything from dessert to roast pork.Īpple varieties are a dizzying world in their own right. Popular in jams, juices, smoothies, and pies, the apple is definitely a fruit for everyone. ![]() Mainly red (¾ apple), green or yellow background, sometimes flat stripe.įewer fruits have as many varieties as an apple. Often sweet, but sometimes also sour or two-part apples. Striped crimson or red, usually on a yellow, white, or light green background (background). Often early apples for culinary use.Ĭream to white apples with almost translucent skin. Smooth-skinned yellow apples, sometimes with a red tint, can turn almost white when ripe. If you are not sure about the ripeness of your samples, look at the apples of both classes. Unripe yellow apples are often placed in this group. Soft, mostly culinary, but also sweet varieties. Is it green, yellow, red, white, or striped? The format below is unique to Montana apples for use in this key and is generally taken from the Bultitude Group method developed by John Bultitude. By using the additional criteria of size, shape, and yield, you can eliminate other possibilities and narrow your search.Īt first glance, the criteria take into account the general appearance of the apple. Some apples can belong to multiple categories with one criterion. Three criteria are used to judge the color of the apple, the overall appearance of the apple, the background color that is red and green apple vs yellow apple, and the overcolor.Īs a good quality, your apple sample must contain several ripe apples from a sunny spot on the tree so that shade does not affect the appearance or taste of the apple. ![]() ![]() ![]() In case the issue still remains, a manual correction of the user profile might be required. Follow the guidance provided by Microsoft here to recover the user profile:.Ensure the Calendar integration is disabled (default disabled as of 4.27.2). In the Advanced Boot Options menu use the arrow keys to select Safe Mode or Safe Mode with.After that the start button and task bar became unresponsive. I ran Ccleaner and Puran utilities reg cleaning tools. Ensure the ClickShare App is updated to version 4.27.2 or higher. Eventually, you may run into various PC issues like the Windows failing to boot or serious problems like the Blue Screen of Death (BSOD) error. 1 Start button task bar not working Hi, Got my Win 10 at the lauch day and have been enjoying it until I decided to do some clean up.The One-Click-Join feature can be disabled through the Calendar Integration toggle in the app settings. The ClickShare App reads the Microsoft Outlook Calendar via the Microsoft Outlook API for the One-Click-Join feature. This bug removes application packages’ permissions from the following Registry path: HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders It brings back the language bar and for me it allowed me to type in Windows search, start menu and Windows 10 apps again. Restart the Process When your Start Menu isnt working, the fault might be linked to the system processes it relies upon to function. Press Win R (to open Run ) Copy paste and press Enter to run this program. More investigation has shown that the ClickShare App triggers a bug in the Microsoft Office API (MAPI). If you are still stuck try this simplest of the solution. Ref: Using System File Checker in Windows 10 Write to us with the updated status and the required information related to Windows performance, for us to be able to assist you further. In Command prompt type sfc /scannow and press enter. Then click troubleshoot, advanced options, start-up settings, restart. Press Windows key X, select Command prompt (Admin) to bring up elevated Command prompt. Before you click 'restart', hold down the shift key until the next screen is displayed (blue). Microsoft OneDrive can’t connect and sync anymore. Incase you arent familiar with how to access safe mode on windows 10, heres how: You press ctrl alt delete, and in the bottom right hand corner you click the power button.Sooner or later, though, you'll probably want. Microsoft Outlook can’t connect and sync anymore. Just double-click their desktop icons, or choose their names from the Start menu, and you're off and working.Windows Search does not respond to mouse clicks on pressing the Search button or Windows S key.The Windows Start Menu does not respond to mouse clicks or the Windows key.When the App starts to read the Outlook Calendar, it can trigger the following issues: We have reports about users experiencing issues with the ClickShare Desktop App. ![]() 8/21/2023 0 Comments Alice eve star trek beyond![]() Assuming those lines from the Star Trek Beyond draft are canon, it appears the starship life wasn't for Carol, and at some point before the third movie kicked off, she departed to work on this timeline's version of that experiment. Not only was the Genesis device a key plot element in Wrath of Khan, but its effects also factored heavily into The Search for Spock. If the item you received doesnt match the listing description, your. But it didn't make it into the final cut.įor those who haven't seen Star Trek II: Wrath of Khan, Project Genesis was intended to take uninhabitable planets and transform them into suitable habitats for humanoid life. STAR TREK BEYOND ALICE EVE AUTOGRAPH Shipping and Returns Seller does not accept returns. I think we had some lines to explain her absence in one of the initial drafts that had her going off to start work on the Genesis project and do sort of very, very early research on that. Now that we know why the writers opted not to include Carol Marcus in Star Trek Beyond and that she's alive out there, that brings up another question: where exactly was she during the recent events? It wasn't said in the movie, but Simon Pegg revealed that there was dialogue from one of the script's drafts suggesting she was going down the same path as her original timeline's self (played by Bibi Besch) in Star Trek II: The Wrath of Khan. Typically, past Star Trek movies took that long when moving through development and into production, then post-production. Seeing as how its only in the script stage and no cast or official title have been announced, a two-plus year wait for fans from now seems about right. Carol was later injured aboard USS Vengeance and watched Khan kill her father, and a year after the superhuman was defeated, she officially joined the Enterprise as a science officer. Paramount has dated Star Trek 4 s theatrical bow for June 9, 2023. The crew soon learned that those torpedoes were actually stasis chambers containing Khan Noonien Singh's men. However, her true identity was eventually revealed, and she explained that she had come on board to investigate the proton torpedoes her father had ordered Kirk to bring onto the Enterprise. ![]() We thought rather than have Carol Marcus be not used to a reasonable capacity, let's just not include her, have her be alive, in canon, and be ready to come back at any time.Īlice Eve's Carol Marcus was originally introduced as Carol Wallace early on in Star Trek Into Darkness, telling Captain Kirk and Spock that Admiral Alexander Marcus had assigned her to the Enterprise. ![]() Rather than throw Carol Marcus in and not have her do anything important, Pegg explained during his appearance on Engage: The Official Star Trek Podcast that they left her out of Star Trek Beyond so they could save her for something meaningful the future. ![]() |
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